Background:- Psoriasis is a common chronic, inflammatory,
proliferative skin disease that generally presents as chronic sharply
demarcated, dull red, scaly plaques, particularly on extensor
prominences and the scalp. ADMA is a naturally occurring chemical
found in blood plasma. It is a metabolic by-product of continual
protein modification processes in the cytoplasm of all human cells.
ADMA interferes with L-arginine in the production of nitric oxide, a
key chemical involved in normal endothelial function and, by
extension, cardiovascular health. Anti-cyclic citrullinated peptides
(anti-CCP) are highly specific diagnostic and prognostic markers for
rheumatoid arthritis (RA). They have been also found in psoriatic
arthritis (PsA), with controversies as regards clinical and radiological
associations.
Objectives:- To estimate level of anti-cyclic citrullinated peptide and
asymmetric dimethyl arginine in sera of Iraqi patients with psoriasis
vulgaris compared to healthy controls.
Patients / Methods:- Fourty (40) psoriasis patients were recruited
from the dermatology Outpatient clinic in Al-Imamain Al-Kadhimain
city hospital from December of 2014 to summer of 2015.Patients body
mass index ( BMI ) and waist circumference (WC) were recorded.
Fasting serum samples were obtained on enrolment. All the patients
did not receive any treatment (locally or systemically), for at least 20
days before enrolment. Age, sex and ( BMI ) matched with fourty(40)
healthy controls were also recruited. Serum ADMA & anti CCP levels
were estimated using an Enzyme-Linked Immunosorbant Assay (
ELISA ) technique (ADMA ELISA Assay Kit-Eagle Biosciences)and
for ant-CCP(Anti CCP ELISA Genway GWB-521226 ) . The patients
group were subdivided into two groups according to the diseases
severity, into mild to moderate psoriasis ,group and severe psoriasis
group.
Results:- Serum levels of anti-CCP and ADMA were statistically
significant elevated in the patients group compared to healthy controls
( p < 0.01 ). Also serum levels of ADMA statistically significantincreased in in severe psoriasis compared to mild-to moderate
psoriasis ( p <0.05 ).
Conclusions:- These data support the view that serum anti-CCP and
ADMA are involved in the pathogenesis of psoriasis, possibly by
induction and maintenance of psoriatic lesion. serum ADMA levels of
psoriasis patients may be an indicator of the disease severity levels of
psoriasis patients may be an indicator of the disease severity
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October 2016
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