Abstract—Objectives: This study examined blood brain natriuretic peptide (BNP) concentrations in newly
diagnosed primary hyperthyroidism (PHT) patients, compared them to healthy controls, and examined their
correlation with age, gender, and biochemical variables triiodothyronine (T3), tetraiodothyronine (T4), and
thyroid stimulating hormone (TSH). The study also sought out a BNP limit for primary hyperthyroidism.
Design and methods: The present study included 45 PHT patients without thyroid medication, heart failure,
acute coronary syndrome, hypertension, renal failure, pregnancy, Cushing’s syndrome, liver disease, and
obesity. In addition, 90 subjects served as the control group in the study. Patients’ and controls' blood sera
were used to measure the concentrations of T3, T4, and TSH by ELFA and BNP by ELISA. Results: The
group with PHT had significantly higher BNP levels than the control group. BNP exhibited a significant positive
correlation with T3 levels and with age in the PHT group, and its level was higher in females. BNP
demonstrated a perfect area under the curve (AUC) where the optimal cutoff value was >32.17, with high sensitivity
and specificity. Conclusions: PHT influences BNP levels, potentially reflecting disease presence and
severity or thyroid-related complications. BNP levels increase with age, with female patients having higher
mean levels. A cutoff value can aid clinicians in diagnosing and managing PHT, guiding evaluation and treatment
decisions. Further research is needed to substantiate findings and investigate the underlying mechanisms
of BNP’s role in thyroid dysfunction.
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2023
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