Diabetic retinopathy (DR) is the chief micro-vascular aggravation of diabetes, and it is accountable for about 10,000 new cases of blindness every year in the USA and affects about 100 million people worldwide. Nitric oxide synthase oxide is family of enzymes catalysing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signalling molecule. It helps modulate vascular tone, insulin secretion, airway tone, peristalsis and is involved in angiogenesis and neural development. By utilizing an ELISA kit for the measurement of the level of NOS in serum, the serum level of NOS was measured in one hundred Iraqi subjects: 30 patients, who have diabetes without DR, 30 patients with diabetic retinopathy (DR), 30 patients who have no diabetes or retinopathy as control group. S. NOS had a significant increase in T2DM and DR patients when related to not diabetic subjects (P<0.001). Glycated Hb revealed a higher significant level in T2DM group and DR group when related to the not-diabetic group (P<0.001) Total Cholesterol revealed Non- significant level in T2DM, DR groups than in non-diabetic controls (P=0.001). Regarding R.B.S level in T2DM, DR groups was high significant when compared with non-diabetic control groups. the serum level of NOS was higher in patients with the NDR than those in DR also it was higher in diabetic patients with retinopathy when compared to control.
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2021/4/2
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