Background
Preeclampsia (PE) is a pregnancy-specific condition, characterized by high blood pressure and proteinuria after 20 weeks of gestation. One of the hypotheses concerning the etiology of PE is vitamin D3 deficiency during pregnancy. Vitamin D3 is especially important during pregnancy as low maternal vitamin D3 stores may contribute to problems like low birth weight as well as an increased risk of maternal comorbidities.
Objectives
To evaluate serum vitamin D3 levels and how they can be affected by the severity of PE at the third trimester of pregnancy.
Methods
This case-control study included a total of 71 pregnant women at the third trimester of pregnancy (41 with PE and 30 without PE as controls). Vitamin D3 serum level was measured by enzyme-linked immune-sorbent assay (ELISA).
Results
The study’s findings showed no significant difference in serum vitamin D3 level (p> 0.05) between controls (14.41±1.41 ng/ml) and PE patients (14.32±1.00 ng/ml). As well, subgroup analysis revealed non-considerable changes between mild PE cases (15.92±1.73 ng/ml) and severe ones (13.07±1.09 ng/ml).
Conclusions
PE and its severity may have no significant effect on serum vitamin D3 levels of pregnant women at the third trimester of pregnancy.
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2021/7/26
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