Background. It is very normal for kids to get tonsillitis. Tonsillectomy is the
most common surgery done on kids who get tonsils over and over again.
When a child is three to ten years old, their tonsils are at their most immune-
boosting. Because of this, the tonsils stand out more during this time and
eventually show age-dependent involution. Aims of the study. Evaluating
the role of vitamin D, interleukin 6, and thyroid-stimulating hormone in
tonsilitis and the relationship of these biomarkers in controlling the severity
of the disease in children. Methodology. A case- control study was
conducted including 30 children with chronic pharyngitis with an average age
of 14.19 years, as well as a control group of 25 healthy children. The study
took place at the Al-Kadhimiya Teaching Hospital from 10/2/2022 to
10/8/2023, after approval by the Research Committee of the College of
Medicine at Al-Nahrain University and obtaining verbal consent from the
parents. Blood samples were collected and the necessary analyzes were
performed. CRP, ASO, and interleukin-6 levels were measured using an
ELISA. The total number of white blood cells was calculated using a Sysmex
CBC device, and the ESR was measured with a Fast ESR device. TSH and
vitamin D levels were analyzed using a Cobas E411 device. Result. The levels
of several biochemical and immune markers were very different between
the patient group and the control group (P< 0.001). In the patient group,
levels of ASOT, CRP, ESR, WBC, TSH, and IL-6 all went up, while levels of
vitamin D went down. The results also showed that TSH and IL-6 levels were
different in men and women with chronic tonsillitis. However, there were no
statistically significant changes in the other indicators (P> 0.05). Conclusions.
The results indicate that there are significant differences in biochemical and
immunological indicators between children with chronic tonsillitis and
healthy children. This can be explained by the increased inflammatory
response in patients, which raises ASOT, CRP, ESR, and IL-6 levels and lowers
vitamin D levels.
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2024/8
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