A prospective during the period October 2020 to April 2021, a comparative study was conducted at the Al-Nahrain University’s
High Institute for Infertility Diagnosis and Assisted Reproductive Technologies (HIIDART). The study’s primary goal was to
determine whether using a dual trigger (FSH and hCG) could increase the likelihood of achieving pregnancy. The participants
This study totaled one hundred women. Before taking part in the study, each participant signed a written informed consent
form that was approved by the Al-Nahrain University’s Ethics Committee before participating. A total of one hundred and one
women participated in the study and were chosen from among those who attended the consultant clinic of the High Institute
for Infertility Diagnosis and Assisted Reproductive Technologies in New York City. On the day of the IUI, An ultrasound scan
of the vaginal cavity was performed after 36 to 48 hours of trigger ovulation to confirm ovulation, measure, and evaluate the
endometrial pattern, and assess sub-endometrial blood flow. FSH, LH, Progesterone, and E2 levels were determined in a blood
sample drawn on the same day for hormonal testing. Luteal phase support was initiated on the day of the IUI and continued
for two weeks by administering 400 mg of progesterone vaginal suppository daily to the patient. Estimation of Beta human
chorionic gonadotropins 14 days after IUI. The distribution of study groups by general characteristics is shown in Table 1.
study patients’ age ranged from 19 to 39 years, with a mean of 29.98 years and a standard deviation (SD) of ± 5.3 years.
The highest proportion of study patients in all groups were aged between 25 and 34 years, overweighed, and complained from
infertility for less than five years’ duration. The comparison in hormonal parameters between study groups at day of IUI is
shown in Table 4.5. The mean FSH level was significantly lower (p = 0.031) in group C than that in groups A and B (6.98 versus
9.06 and 9.3 IU/L, respectively). The mean E2 level was significantly higher (p = 0.001) in-group A than that in groups B and C
(69.62 versus 53.32 and 36.65 pg/mL, respectively). The comparison in percentage of change in hormonal parameters at day
of IUI compared to that at day of trigger according pregnancy outcome is shown in table 4.16. There are no significant differences
between women who get pregnant and those who don’t, in percentage of change of all other hormonal parameters at
day of IUI (p ≥ 0.05) compared to that at day of trigger
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2022
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