Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology.
Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members
enormously affect the innate immune system.
AIM: Study the changes in the levels of Interleukin-1ß and Interleukin-27 in the stimulated and non-stimulated cycle
(by gonadotrophin) in polycystic ovarian syndrome women.
METHODS: Fifty-eight infertile women with polycystic ovary syndrome (PCOS) have been included in this research
article. Twenty-nine of them did not undergo ovulation induction (OI) protocols, while the other 29 were under
ovulation induction (OI) therapy. Interleukin-1ß and Interleukin-27 measured in both groups, in the stimulated cycle
just before administration of HCG and on the 2nd day of the menstrual cycle in the non-stimulated females.
RESULTS: Both interleukins have been significantly more significant in the ovulation stimulated group than the nonstimulated one, with p-value of (0.04) for interleukin -1ß and (0.02) for interleukin-27.
CONCLUSION: The ovulation processes involve an increase in the inflammatory process, as demonstrated by the
rise in these interleukins’ levels. This increase is more prominent in the process of ovulation induction.
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2022
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