ABSTRACT
Gliomas are the most common primary of the central nervous system, representing
81% of malignant brain tumors. The exact causes of gliomas are still unclear; however an
association of certain risk factors was well documented. The current study aimed to
investigate the association of anti-human cytomegalovirus (HCMV)IgG and IgM antibodies
with the incidence of glioma. A total of 100 glioma patients from different local hospitals,
and 40 apparently healthy control individuals were recruited for this study. Serum samples
from each participant were obtained, specific anti-HCMV IgG and IgM antibodies were
estimated using ELISA technique. Eighty-five percent of glioma patients gave positive result
for anti-HCMV IgG antibodies, compared to 72.5% among control (OR = 2.779, 95% CI =
1.049-7.358, p = 0.04). There are no significant differences in the distribution of these
antibodies among different age classes of glioma patients. For IgM, only14% of glioma
patients gave positive results compared to 10% in control (OR = 1.737, 95% CI = 0.47-6.421,
p = 0.408 Previous infection as indicated by the presence of anti-HCMV IgG antibody may
contribute in the initiation of gliomas.
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August .2014
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