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ASSOCIATION OF ANTI-HUMAN IGG AND IGM ANTIBODIES WITH THE INCIDENCE OF GLIOMAS
حيدر أحمد شمران
Authors : Haidar A.Shamran
ABSTRACT Gliomas are the most common primary of the central nervous system, representing 81% of malignant brain tumors. The exact causes of gliomas are still unclear; however an association of certain risk factors was well documented. The current study aimed to investigate the association of anti-human cytomegalovirus (HCMV)IgG and IgM antibodies with the incidence of glioma. A total of 100 glioma patients from different local hospitals, and 40 apparently healthy control individuals were recruited for this study. Serum samples from each participant were obtained, specific anti-HCMV IgG and IgM antibodies were estimated using ELISA technique. Eighty-five percent of glioma patients gave positive result for anti-HCMV IgG antibodies, compared to 72.5% among control (OR = 2.779, 95% CI = 1.049-7.358, p = 0.04). There are no significant differences in the distribution of these antibodies among different age classes of glioma patients. For IgM, only14% of glioma patients gave positive results compared to 10% in control (OR = 1.737, 95% CI = 0.47-6.421, p = 0.408 Previous infection as indicated by the presence of anti-HCMV IgG antibody may contribute in the initiation of gliomas.

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August .2014