Vulvovaginal candidacies usually are caused by C. Albicans but can occasionally be caused by
other Candida spp. or yeasts. Typical symptoms of VVC include pruritus, vaginal soreness, dyspareunia,
external dysuria, and abnormal vaginal discharge. Candida Albicans remains the dominant species responsible
for RVVC; however optimal management of RVVC requires species determination and effective treatment
measures are best if species-specific. Beta defensin has a role direct fungicidal activity. In the event of Th2-
skewed responses to Candida, however, the development of Th2 cells by IL-4 signaling and subsequent
cytokine production (e.g. IL-10) are known to dampen the Th1-mediated protection, leading to susceptibility to
Candida infection. Aim of the study: Determination the role of each of Beta defensin and IL-4 in recurrent
Vulvovaginal Candidiasis among different Iraqi women.
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October 2020
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