Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopment disease resulting from complex interaction between genetic and environmental factors.
Aim: This study aimed to detect if there is association between rubella virus and ASD.
Materials and methods: This case control study conducted from November 2016 to June 2017, blood samples were collected from forty ASD patients whom attended to the central teaching hospital for children in Al-Eskan city also this study included forty apparently healthy children as a control group. Enzyme Linked Immuno-Sorbent Assay (ELISA) technique was used for investigation of anti rubella antibodies in sera samples.
Results: The present results demonstrated significant difference regarding IgG sero-positivity of rubella virus between studied groups, there was 6 cases among 40 autistic patients with IgG sero-negative while all the controls have IgG positive ( P value =0.025).
Conclusion: Individuals with sero-negative of anti-rubella IgG may consider at risk for ASD.
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May 2018
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