On Wednesday, 18th September 2024, the Ph.D. candidate Raed Saad Louti from the Department of Pharmacology successfully defended his dissertation entitled:
**"Effects of Liquiritin and Orientin Phytochemicals on Nephropathy Complicating High-Fat Diet and Streptozocin-Induced Type 2 Diabetes Mellitus in Rats."**
In an attempt to explore new therapeutic agents, the current study investigated the protective effect of Liquiritin and Orientin against diabetic nephropathy (DN) caused by a high-fat diet and streptozotocin-induced Type 2 diabetes mellitus in rats.
The combination of Metformin and Liquiritin led to a significant reduction in most pathological histological changes. While Metformin alone did not achieve this, Liquiritin notably decreased renal homogenate levels of inflammatory and oxidative markers. Orientin significantly reduced serum creatinine levels (0.29 ± 0.19), urea (39.83 ± 8.92), and prevented the progression of most pathological histological changes, recording 0 in this group. When comparing the two flavonoids, Orientin appeared more active and was able to restore inflammatory and oxidative markers near the normal values of the healthy control group.
Both Metformin and Liquiritin demonstrated a significant improvement against DN, reducing most pathological histological changes, oxidative stress, and inflammatory markers. Orientin, however, completely prevented most pathological histological changes associated with DN, showing functional improvement and a significant reduction in inflammatory and oxidative markers in kidney tissues.
The defense committee consisted of:
1. Prof. Dr. Abdul Karim Hamid Abdul (Chair)
2. Prof. Dr. Ria Suleiman Baban (Member)
3. Prof. Dr. Ban Jumaa Qasim (Member)
4. Assoc. Prof. Dr. Mohammed Qasim Yahya (Member)
5. Assoc. Prof. Dr. Fouad Kadhim Kata (Member)
6. Prof. Dr. Adeeb Ahmed Kadhim (Supervisor and Member)
7. Prof. Dr. Arif Sami Malik (Supervisor and Member)
The dissertation was accepted with distinction.
 
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